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T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice III. ROLE OF LYT 1+2− NON-HELPER T CELLS IN THE SUPPRESSION.
- Source :
- Immunology; Nov82, Vol. 47 Issue 3, p525-530, 6p
- Publication Year :
- 1982
-
Abstract
- A large number of cells which can replicate vesicular stomatitis virus (VSV) were generated in pokeweed mitogen (PWM)-stimulated cultures of normal mouse spleen cells. The optimal dose of PWM for the generation of VSV-replicating cells was within the range 25 and 50 µg/ml, which had previously been shown to be optimal for the induction of suppressor cells. The VSV-replicating cells in this system were shown to be Thy 1<superscript>+</superscript> and Lyt 1+2<superscript>-</superscript>. These cells, however, were unlikely to be helper T cells, but may be a subset of T cells involved in suppression. Thus, inoculation of VSV into a PWM-stimulated culture of spleen cells resulted in marked augmentation of polyclonal immunoglobulin production. Further, it was shown that the suppressive activity of T cells which had been precultured with a high dose of PWM was abolished by the infection with this virus. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 47
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13942085