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Antigen-induced suppression in man: non-specific suppression mediated via OKT8+ cells.
- Source :
- Immunology; Aug84, Vol. 52 Issue 4, p589-598, 10p
- Publication Year :
- 1984
-
Abstract
- We have developed a simple assay for human peripheral-blood suppressor cells induced by soluble protein antigens. Suppressor cells were obtained from 6-day cultures in the presence of tetanus toxoid or PPD and were assayed in co-cultures with fresh autologous PBLs. The proliferative response in this second culture showed significant suppression varying from 50% to 90%. The suppressor cells are OKT8-positive, resistant to X irradiation and nonspecific in their function. They do not impede either the function or production of TCOF in the secondary culture but we are unable to detect a non-specific suppressor factor made by these cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNOSUPPRESSION
SUPPRESSOR cells
ANTIGENS
IMMUNE system
T cells
BIOLOGICAL assay
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 52
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13946992