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α-Macroglobulin-induced release of anti-Ig-coated particles from a subpopulation of rabbit B lymphocytes.
- Source :
- Immunology; Jul83, Vol. 49 Issue 3, p519-528, 10p
- Publication Year :
- 1983
-
Abstract
- Approximately half of the rosettes formed by rabbit Ig<superscript>+</superscript> lymphocytes (B cells) and anti-Ig-coated erythrocytes or glutaraldehyde-fixed bacteria are dissociated upon the addition of rabbit serum. Rabbit serum was fractionated and the rosette-dissociating activity was found in purified preparations of rabbit α<subscript>1</subscript>- and α<subscript>2</subscript>-macroglobulins. Studies designed to elucidate the mechanism of rosette dissociation suggested that the α-macroglobulins dissociated rosettes by causing the release or proteolytic cleavage of the membrane proteins complexed with the anti-Ig-coated particles. These data suggest that the α-macroglobulins may have a role in the interaction of B lymphocytes with particulate antigens. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 49
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13947751