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Ly 1+2− suppressor T cells down-regulate the generation of Ly1−2+ effector T cells during progressive growth of the P815 mastocytoma.
- Source :
- Immunology; Jan1985, Vol. 54 Issue 1, p47-56, 10p
- Publication Year :
- 1985
-
Abstract
- It has been shown that progressive growth of the P815 mastocytoma in its semisyngeneic B6D2 host results, between days 6 and 9 of tumour growth, in the generation of Ly 1<superscript>-</superscript>2<superscript>+</superscript> T cells which are capable, on passive transfer, of causing the regression of an established tumour in γ-irradiated recipients, and of T cells which are capable of lysing P815 tumour cells in vitro. After 9 days of tumour growth, these effector T cells are progressively lost; this is associated with the progressive acquisition of Ly 1<superscript>+</superscript>2<superscript>-</superscript> suppressor T cells which are capable of inhibiting the expression of passively transferred immunity against an established tumour in T-cell deficient recipients. The results are consistent with the hypothesis that this P815 mastocyroma grows progressively, in spite of its immunogenicity, because it evokes the generation of suppressor T cells before enough effector T cells are generated to reject it. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 54
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13948453