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Direct blockade of antigen-reactive B lymphocytes by immune complexes. An 'off' signal for precursors of IgM-producing cells provided by the linkage of antigen- and Fc-receptors.
- Source :
- Immunology; Jul78, Vol. 35 Issue 1, p151-157, 7p
- Publication Year :
- 1978
-
Abstract
- Antigen-antibody complexes efficiently inhibit the induction of antibody formation. Using Mishell-Dutton cultures, it can be demonstrated that neither T cells nor their products are required for this inhibition of IgM PFC formation. The blockade is at the level of B cells and cannot be overcome by LPS or TRF. The data demonstrate that cross-linking of antigen- and Fc-receptors by antigen-antibody complexes is a blocking signal for B cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- LYMPHOCYTES
ANTIGENS
B cells
LEUCOCYTES
T cells
IMMUNOGLOBULINS
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 35
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13948486