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Effect of irradiation on the precursor, activated and memory suppressor T cells for delayed-type hypersensitivity to sheep erythrocytes in mice.
- Source :
- Immunology; Dec84, Vol. 53 Issue 4, p669-675, 7p
- Publication Year :
- 1984
-
Abstract
- The relative radiosensitivities of precursor (Tsp), activated (Ts) and memory (Tsm) suppressor T cells for delayed-type hypersensitivity (DTH) to sheep red blood cells (SRBC) were investigated in mice. Spleen cells from CBA mice, primed i.v. with 10<superscript>9</superscript> SRBC 3–4 days previously, contain specific Ts cells which substantially impair the induction of DTH to SRBC in normal syngeneic recipients. Exposure of mice to 400 rad irradiation 1 day before the priming completely eliminated the subsequent development of Ts cells. In contrast, 3 days after the priming injection, Ts cell activity in mice is resistant to doses higher than 600 rads. Mice primed 40 days previously with 10<superscript>9</superscript> SRBC contain Ts-cell memory which can be readily recalled by i.p. injection of 10<superscript>8</superscript> SRBC, The secondary Ts cells which specifically inhibit DTH induction can be demonstrated adoptively in normal recipients. Mice were exposed to various doses of irradiation 40 days after the priming and 1 day before the i.p. injection, Ts memory was significantly reduced by 300 rads and was completely abrogated by 400 rads. The relative radiosensitivities of the three subsets of suppressor T cells are in the order of Tsm = Tsp > Ts. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
IRRADIATION
ALLERGIES
ERYTHROCYTES
LYMPHOCYTES
LEUCOCYTES
BLOOD cells
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 53
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13951175