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T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. II. MECHANISM OF THE INDUCTION OF SUPPRESSOR T CELLS.
- Source :
- Immunology; Jul82, Vol. 46 Issue 3, p583-587, 5p
- Publication Year :
- 1982
-
Abstract
- The regulation of pokeweed-mitogen (PWM) induced polyclonal immunoglobulin (Ig) production by suppressor T cells was investigated in mice. Generation of Ig-producing cells in PWM-stimulated culture was helped by T ceils and the helper activity was markedly augmented by X-irradiation, suggesting that the suppressor cells which may coexist in the helper source were abolished by X-irradiation. Present study also provided direct evidence for the involvement of suppressor cells in PWM-induced Ig production. Thus, suppressor cells could be induced by prestimulation of splenic T cells with high doses of PWM for 3–4 days. Both the precursor and effector suppressor T cells in this system were found to be Lyt 1<superscript>-</superscript>2<superscript>+</superscript>. It was further shown that although the Lyt 1<superscript>-</superscript>2<superscript>+</superscript> subset could be directly stimulated by PWM to generate suppressor cells, the presence of Lyt 1<superscript>+</superscript>2<superscript>-</superscript> cells in the culture markedly enhanced the generation of Lyt 1<superscript>-</superscript>2<superscript>+</superscript> suppressor cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 46
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13953998