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Differences in putative minor histocompatibility but not Igh genes can prevent T-cell priming and T-B co-operation in the response of mice to sheep erythrocytes.
- Source :
- Immunology; Jul82, Vol. 46 Issue 3, p643-651, 9p
- Publication Year :
- 1982
-
Abstract
- A positive association has been observed in Igh allotype ‘congenic’ mice between skin graft rejection and a block to effective T-B co-operation in the development of both IgM and IgG responses to sheep erythrocytes. Mismatch of Igh alone is insufficient for such a block to become apparent since pairs of Igh-allotype congenic strains of mice which reciprocally accept skin grafts for at least 5 weeks, show successful positive co-operation (help) between T and B cells. The observed block is manifest both during the education (priming) of T cells in irradiated (first stage) recipients and during co-operation between primed T cells and unprimed B cells in second stage irradiated ‘syngeneic’ recipients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 46
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13954040