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Cell-mediated immunity in experimental murine dermatophytosis. I. TEMPORAL ASPECTS OF T-SUPPRESSOR ACTIVITY CAUSED BY <em>TRICHOPHYTON QUINCKEANUM</em>.
- Source :
- Immunology; Nov84, Vol. 53 Issue 3, p457-464, 8p
- Publication Year :
- 1984
-
Abstract
- Cutaneous dermatophyte infections caused by Trichophyton quinckeanum were established in various strains of mice. All congenic BALB/B (H-2<superscript>b</superscript>), BALB/c (H-2<superscript>d</superscript>) and BALB/K(H-2<superscript>k</superscript>) strains showed high susceptibility to dermatophyte infection. Susceptibility is independent of MHC phenotype, since other strains with corresponding H-2 haplotypes such as C57BL/6 (H-2<superscript>b</superscript>), DBA/2 (H-2<superscript>d</superscript>) and CBA (H-2<superscript>k</superscript>) were resistant to the disease. During the acute phase of infection in BALB/c mice, the in vitro biastogenic responses of regional lymph node cells was suppressed. Suppression was observed for both the T cell mitogens concanavalin A and phytohaemagglutinin, and for the B cell mitogen lipopolysaccharide. A series of cell mixing experiments revealed that lymph node cells from infected mice were able to suppress the T cell and B cell mitogenic responses of lymph node cells from normal mice. Suppression was mediated by T cells and abrogated by treatment of lymph node ceils with either monoclonal anti-thy-1.2 or anti-Ly-2.2 and complement. In this report, we discuss the possibility that T-suppressor mechanism mediated by cells bearing the Ly-2<superscript>+</superscript> phenotype and activated during dermatophyte infection may determine the course of the disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- DERMATOPHYTES
TRICHOPHYTON
LABORATORY mice
LYMPH nodes
T cells
MITOGENS
B cells
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 53
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13954395