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Purification and properties of a factor from leukaemic T cells which non-specifically enhances the antibody response.
- Source :
- Immunology; Jan81, Vol. 42 Issue 1, p25-35, 11p
- Publication Year :
- 1981
-
Abstract
- A non-specific immunoenhancing factor from leukaemia owl monkey peripheral T lymphocytes has been purified and partially characterized. Owl monkey enhancing factor, OMEF, is a glycoprotein with a molecular weight of 39,000 and an isoelectric point of pH 6·5. It acts at nanogram levels on day 2 of the in vitro immune response to enhance the number of plaque-forming cells produced to sheep red blood cells in a routine assay system but has no effect when added on day 0 to this system. Antibodies to the purified factor have been produced and binding studies show that OMEF cross-reacts with other anti- sera raised to an enhancing factor produced by a mixture of human allogeneic lymphocytes but shows no cross-reactivity to a murine enhancing factor. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 42
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13970256