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Histopathological correlation of diffusion basis spectrum imaging metrics of a biopsy-proven inflammatory demyelinating brain lesion: A brief report.
- Source :
- Multiple Sclerosis Journal; Dec2019, Vol. 25 Issue 14, p1937-1941, 5p, 1 Diagram, 1 Graph
- Publication Year :
- 2019
-
Abstract
- Diffusion basis spectrum imaging (DBSI) models diffusion-weighted magnetic resonance imaging (MRI) signals as a combination of discrete anisotropic diffusion tensors and a spectrum of isotropic diffusion tensors. Here, we report the histopathological correlates of DBSI in the biopsied brain tissue of a patient with an inflammatory demyelinating lesion typical of multiple sclerosis (MS). Increased radial diffusivity (marker of demyelination), decreased fiber fraction (apparent axonal density), elevated nonrestricted isotropic fraction (marker of vasogenic edema), but unchanged axial diffusivity (marker of integrity of residual axons) seen in the lesion appeared consistent with histopathological findings of inflammatory demyelination with relative axonal sparing. Our report supports the application of DBSI as a biomarker in human studies of MS. [ABSTRACT FROM AUTHOR]
- Subjects :
- DIFFUSION magnetic resonance imaging
BRAIN damage
MYELIN sheath diseases
DIFFUSION
Subjects
Details
- Language :
- English
- ISSN :
- 13524585
- Volume :
- 25
- Issue :
- 14
- Database :
- Complementary Index
- Journal :
- Multiple Sclerosis Journal
- Publication Type :
- Academic Journal
- Accession number :
- 139825277
- Full Text :
- https://doi.org/10.1177/1352458518786072