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Radical Monofluoroalkylative Alkynylation of Olefins by a Docking–Migration Strategy.
- Source :
- Angewandte Chemie International Edition; 12/2/2019, Vol. 58 Issue 49, p17646-17650, 5p
- Publication Year :
- 2019
-
Abstract
- A radical‐mediated monofluoroalkylative alkynylation of alkenes is disclosed for the first time. The reaction demonstrates a remarkably broad substrate scope in which both activated and unactivated alkenes are suitable starting materials. The concurrent addition of an alkynyl and a monofluoroalkyl group onto an alkene proceeds through a docking–migration sequence, affording a vast array of valuable fluoroalkyl‐substituted alkynes. Many complex natural products and drug derivatives are readily functionalized, demonstrating that this method can be used for late‐stage alkynylation. [ABSTRACT FROM AUTHOR]
- Subjects :
- DRUG derivatives
ALKENES
NATURAL products
ALKYNES
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 58
- Issue :
- 49
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 139841695
- Full Text :
- https://doi.org/10.1002/anie.201910514