Changes of Numb and TFR1 expression in ovarian cancer tissue and their clinical pathological value.

Objective: To investigate the changes of Numb and TFR1 expression in ovarian cancer tissue and their clinical pathological value. Methods: 90 patients with ovarian cancer underwent radical operation in Pidu District People's Hospital, the First Affiliated Hospital of Chengdu Medical College and Mianyang Central Hospital between August 2015 and April 2018, 115 patients with ovarian chocolate cyst underwent surgery during the same period, and intraoperative lesion tissue samples of the two groups were collected and enrolled in ovarian cancer group and ovarian chocolate cyst group respectively. The expressions levels of Numb, TFR1 gene as well as ovarian cancer-related proliferation, invasion and autophagy genes in ovarian lesions were detected. Pearson test was used to evaluate the correlation of Numb and TFR1 gene expression in ovarian cancer tissues with proliferation, invasion and autophagy activity of cancer cells. Results: Numb mRNA expression in lesions of ovarian cancer group was lower than that of ovarian chocolate cyst group whereas TFR1 mRNA expression was higher than that of ovarian chocolate cyst group; proliferation genes C3G, Clusterin, FUNDC1, PIWIL4 and TNFAIP8 mRNA expression were higher than those of ovarian chocolate cyst group whereas Let-7i mRNA expression was lower than that of ovarian chocolate cyst group; invasion genes BRMS1, XAV939 and OVCA1 mRMA expression were lower than those of ovarian chocolate cyst group whereas CUL4A and MTA1 mRNA expression were higher than those of ovarian chocolate cyst group; autophagy genes FTY720 and Beclin1 mRNA expression were lower than those of ovarian chocolate cyst group whereas NAC-1 mRNA expression was higher than that of ovarian chocolate cyst group. Correlation analysis showed that the Numb and TFR1 gene expression in ovarian cancer tissues were directly correlated with the proliferation, invasion and autophagy activity of cancer cells. Conclusion: The abnormal decrease of Numb gene expression and the abnormal increase of TFR1 gene expression in ovarian cancer tissues are directly correlated with the malignant biological behaviors of cancer cells. [ABSTRACT FROM AUTHOR]