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Interaction of antibody-aggregated C4 and guinea-pig red cells: coagglutination phenomenon of Bordet and Gengou.
- Source :
- Immunology; Aug81, Vol. 43 Issue 4, p699-706, 8p
- Publication Year :
- 1981
-
Abstract
- The component of bovine serum (coagglutinogen) responsible for coagglutination of guinea-pig red cells has been shown to be C4, as anticipated from our previously reported findings on human serum. To effect coagglutination, the C4 needs to be aggregated by antibody; thereby probably increasing the avidity of the C4 for the receptors on guinea-pig red cells. The coagglutinating activity is lost if univalent Fab anti-C4 is used, but it can be restored by adding IgG antibody to the Fab. A procedure is described for producing antibody reagents to human or bovine C4 by injecting guineapigs with well-washed coagglutinated guinea-pig red cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNOGLOBULINS
GENES
ERYTHROCYTES
IMMUNOLOGY
SERUM
GUINEA pigs
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 43
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13989800