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The goldfish immune response. I. CHARACTERIZATION OF THE HUMORAL RESPONSE TO PARTICULATE ANTIGENS.
- Source :
- Immunology; Aug81, Vol. 43 Issue 4, p755-762, 8p
- Publication Year :
- 1981
-
Abstract
- Anti-red blood cells (RBC) and anti-hapten antibody synthesis were studied in the goldfish, Carassius auratus. Spontaneous haemagglutination titres were found against all the antigens tested. A weak secondary response was observed in RBC-primed fish boosted during the end-phase of the primary antibody production. However, when the second antigenic challenge was performed during the early exponential phase of a primary stimulation, an important amplified response was obtained. The antibody production and immunological memory can be dissociated: no antibody synthesis occurred in glutaraldehyde-fixed RBC (F-RBC) primed animals but a characteristic amplified response was obtained when untreated or F-RBC were given to F-RBC primed animals. The amplified response to sheep red blood cells (SRBC) was significantly inhibited when fish were primed with a mixture of SRBC and Xenopus red blood cells (SRBC). demonstrating an antigenic competition phenomenon. Studies on anti-trinitrobenzene responses confirm the efficiency of E. coli lipopolysaccharide as a carrier for fish anti-hapten immunization. The kinetics and regulation of antibody synthesis in fish are discussed in relation to the described results. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNE response
GOLDFISH
IMMUNOGLOBULINS
ANTIGENS
ERYTHROCYTES
MEMORY
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 43
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13989851