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Mitochondria-Mediated Programmed Cell Death in Saccharomyces Cerevisiae Induced by Betulinic Acid is Accelerated by the Deletion of PEP4 Gene.
- Source :
- Microorganisms; Nov2019, Vol. 7 Issue 11, p538-538, 1p
- Publication Year :
- 2019
-
Abstract
- In this work, using Saccharomyces cerevisiae as a model, we showed that BetA could inhibit cell proliferation and lead to lethal cytotoxicity accompanying programmed cell death (PCD). Interestingly, it was found that vacuolar protease Pep4p played a pivotal role in BetA-induced S. cerevisiae PCD. The presence of Pep4p reduced the damage of BetA-induced cells. This work implied that BetA may induce cell death of S. cerevisiae through mitochondria-mediated PCD, and the deletion of Pep4 gene possibly accelerated the effect of PCD. The present investigation provided the preliminary research for the complicated mechanism of BetA-induced cell PCD regulated by vacular protease Pep4p and lay the foundation for understanding of the Pep4p protein in an animal model. [ABSTRACT FROM AUTHOR]
- Subjects :
- APOPTOSIS
DELETION mutation
SACCHAROMYCES cerevisiae
CELL death
PROTEIN models
Subjects
Details
- Language :
- English
- ISSN :
- 20762607
- Volume :
- 7
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Microorganisms
- Publication Type :
- Academic Journal
- Accession number :
- 139937893
- Full Text :
- https://doi.org/10.3390/microorganisms7110538