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T-cell control of IgA production I. DISTRIBUTION, ACTIVATION CONDITIONS AND CULTURE OF ISOTYPE-SPECIFIC REGULATORY HELPER CELLS.
- Source :
- Immunology; Sep85, Vol. 56 Issue 1, p81-91, 11p
- Publication Year :
- 1985
-
Abstract
- The capacity of T cells from different sites to augment IgA production by LPS-stimulated B cells has been investigated. Peyer's patch T lymphocytes activated with Con A induced up to a 20-fold increase in IgA production. The effect was isotype-specific, in that no consistent effect on IgG and a diminution of IgM synthesis were observed. Less activity was recorded in spleen and mesenteric lymph node T cells. Optimal activation of the Thy 1<superscript>+</superscript> Lyt 1 <superscript>+</superscript>2<superscript>-</superscript> helper cells required the addition of splenic adherent cells and the elimination of Thy 1<superscript>+</superscript> Lyt 2<superscript>-</superscript> suppressor cells prior to activation. T lymphocytes maintained regulatory activity for several months after expansion in medium supplemented with IL-2 and are now being cloned. We conclude that IgA production is under control of T cells sited preferentially, but not exclusively, in gut-associated lymphoid tissue, and that these T cells can augment IgA production by B lymphocytes from sites with low commitment to production of this isotype. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 56
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 14003368