Back to Search
Start Over
Genetic control of immunity to <em>Trichinella spiralis</em> in mice: capacity of cells from slow responder mice to transfer immunity in syngeneic and F1 hybrid recipients.
- Source :
- Immunology; Oct85, Vol. 56 Issue 2, p203-211, 9p
- Publication Year :
- 1985
-
Abstract
- Mice of the C57BL/10 (B 10) strain are slow responders to infection with T. spiralis in terms of ability to expel worms from the intestine. Compared with rapid-responder NIH mice, infection stimulates a slower and reduced blast cell response in the draining mesenteric lymph node (MLN). Transfer of immune cells from the MLN (MLNC) does not accelerate worm expulsion from naive B 10 recipient mice, even though MLNC from this strain effectively transfer immunity to (B10 × NIH) F<subscript>1</subscript> recipients. In common with other B 10 background mice C57BL/10 show an infection-dose related suppression of immunity to T. spirolis. Such suppression does not appear to determine the response to MLNC, as adoptive transfer into 810 recipients was not enhanced by reducing the level of challenge infection given, and transfer into F<subscript>1</subscript> recipients was unaffected by simultaneous transfer of lymphocyte populations from donors infected at a level which would induce suppression. A hypothesis is proposed which relates slow response status to (i) the inherent capacity of the intestinal inflammatory component of worm expulsion, and (ii) the outcome of infection-dose related stimulatory and suppressive influences acting on the two interacting lymphocyte components of expulsion. The relevance of H-2-linked and non-H-2 genes to the control of the response is discussed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 56
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 14003585