Suppression of induced erythrocyte autoantibodies is dependent on Lyt 1 cells.

When normal mice are immunized with rat RBC, autoantibodies to mouse red cells and antigen-specific suppressor cells are generated. Suppressor cell activity is found in T-enriched populations and suppresses only the induction of autoantibody, not ongoing or secondary autoantibody responses. Using anti- bodies lytic for either B cells or distinct T-cell subpopulations, we are able to show that suppression is dependent on the presence of Lyt 1 ⁺ T cells. [ABSTRACT FROM AUTHOR]