Back to Search
Start Over
Thymic-dependence and immune memory in mice vaccinated with meningococcal polysaccharide group B complexed to outer membrane protein.
- Source :
- Immunology; Mar1986, Vol. 57 Issue 3, p425-430, 6p
- Publication Year :
- 1986
-
Abstract
- Athymic mice were capable of producing IgM antibodies to B polysaccharide of N. meningitidis when immunized with the polysaccharide complexed to outer membrane proteins, whereas no immunogenicity could be demonstrated with the purified polysaceharide. Transfer of T cells to athymic cells demonstrated that the primary anti-B response was truly thymus-independent but the bulk of the secondary response was thymus-dependent. Transfer of T and B cells purified from spleens of immune mice into irradiated recipients showed the presence of memory T cells, but no memory B cells could be found. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
PROTEINS
IMMUNOGLOBULINS
IMMUNITY
POLYSACCHARIDES
CHITIN
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 57
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 14004425