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Cyclophosphamide (Cy)-facilitated adoptive immunotherapy of a Cy-resistant tumour. Evidence that Cy permits the expression of adoptive T-cell mediated immunity by removing suppressor T cells rather than by reducing tumour burden.
- Source :
- Immunology; Sep88, Vol. 65 Issue 1, p87-92, 6p
- Publication Year :
- 1988
-
Abstract
- A cyclophosphamide (Cy)-resistant immunogenic tumour, the L51I 78Y lymphoma, was used to demonstrate that Cy-treatment of a host bearing this tumour enables passively transferred tumour- sensitized T cells to cause complete tumour regression without any need for Cy to cause a reduction in tumour burden. It was shown that whereas infusion of tumour-sensitized T cells from immune donors had very little effect on growth of the tumour, and whereas treatment with 150 mg/kg of Cy caused appreciable enhancement of tumour growth, combination therapy with Cy plus immune T cells caused complete tumour regression and resulted in long-term survival. Evidence that Cy treatment facilitated the expression of adoptive immunity against the L5178Y lymphoma by eliminating tumour-induced suppressor T cells consisted of the demonstration that tumour regression caused by combination treatment with Cy and immune T cells could be inhibited by infusing the recipient with Cy-sensitive, L3T4<superscript>+</superscript> T cells from tumour-bearing but not from normal donors. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
TUMORS
LYMPHOMAS
IMMUNITY
IMMUNOSUPPRESSION
IMMUNOTHERAPY
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 65
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 14004442