Variable-region sequence homologies of human <em>K</em>-chains with idiotypic serologic similarities.

An antibody to the V-region of a kI light chain has been used to detect other human sc-chains with similar idiotypic specificitics that appear to be related to complementarity-determining regions (CDR). Four such proteins, three of which react with this antibody, have been sequenced. While the proteins show relatively strong sequence similarities in their CDR2 regions, the relatively high degree of homology in a localized segment of the V-region of A-chains detected by this method was not observed here. [ABSTRACT FROM AUTHOR]