Back to Search
Start Over
<em>In vivo</em> modulation of antigen presentation generates Ts rather than TDH in HSV-1 infection.
- Source :
- Immunology; Mar1987, Vol. 60 Issue 3, p419-423, 5p
- Publication Year :
- 1987
-
Abstract
- The role of suppressor cells in control of persistent infections may be of profound importance. Whether a positive immune response or suppression of immunity is generated at the time of initial exposure to pathogens causing such infections may in part be due to the nature of the initial antigen presentation to the specific cells of the immune system. We have shown that in vivo modulation of epidermal APCs by an environmentally encountered stimulus (UV-B light exposure) and subsequent transfer of these APCs together with live HSV-1 to naive syngeneic recipients is sufficient to generate suppression of DH rather than DH to HSV-1. This suppression is T-cell mediated and specific for HSV-l. The phenotype of the Ts cell induced by epidermal cell transfer is Thyl<superscript>+</superscript> L3T4<superscript>+</superscript> Ly2<superscript>-</superscript>. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTIGENS
CELLS
IMMUNE response
PATHOGENIC microorganisms
T cells
LYMPHOCYTES
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 60
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 14006599