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Immune responses in newly developed short-lived SAM mice II. SELECTIVELY IMPAIRED T-HELPER CELL ACTIVITY IN <em>IN VITRO</em> ANTIBODY RESPONSE.
- Source :
- Immunology; Nov87, Vol. 62 Issue 3, p425-429, 5p
- Publication Year :
- 1987
-
Abstract
- New short-lived strains of mice (SAM-P), which have been developed by Takeda et al. (1981), show a defective antibody response to T dependent (TD) antigen in vitro, as demonstrated in the accompanying paper (see page 419). In the present study, we investigated the cellular site of the defect, using a cell culture system. In this paper, it is demonstrated that T-helper (Th) cell activity for the antibody response to TD antigen is impaired, while other cellular immune responses, e.g. mixed leucocyte reaction, cytotoxic T-lymphocyte response, and delayed-type hypersensitivity reaction, are normal. These results suggest that the defect in T-helper subset is limited in helper function for the antibody response, and that the helper function for the cell-mediated immune responses is intact. These two functions of the T-helper subset are apparently regulated in a different manner. The SAM-P strains of mice may thus serve as an appropriate model for studying functional heterogeneity in T-helper/inducer cell subsets. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
LEUCOCYTES
IMMUNOGLOBULINS
ANTIGENS
LYMPHOCYTES
CELL culture
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 62
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 14008035