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Effect of stimulation and blockade of mononuclear phagocyte system on the induction of suppressor T cells of delayed footpad reaction to SRBC in mice.
- Source :
- Immunology; Jun81, Vol. 43 Issue 2, p241-247, 7p
- Publication Year :
- 1981
-
Abstract
- The role of mononuclear phagocyte system (MPS) in the induction of suppressor T cells which depress the delayed footpad reaction to sheep erythrocytes (SR BC) was studied in mice in which MPS was blocked or stimulated. Colloidal carbon and diethyl- stilbestrol were used for blockade and stimulation respectively. Adoptive transfer of suppressor T cells was achieved by spleen cells of mice immunized intra- peritoneally with varying doses of SRBC. In non-treated mice, 1 × 10<superscript>9</superscript> SRBC were required to induce suppressor T cells, while 6 × 10<superscript>8</superscript> could not induce the suppressor T cells. In MPS-blocked mice, however, even 6 × 10<superscript>8</superscript> SRBC could induce the suppressor T cells. On the other hand, 3 × 10<superscript>8</superscript> SRBC were required for the induction of suppressor T cells in MPS-stimulated mice. These results suggest that the activity of macrophages as scavenger cells modulates the subsequent induction of suppressor T cells after immunization with high doses of SRBC. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
LIVESTOCK
IMMUNITY
LYMPHOCYTES
PHAGOCYTES
IMMUNIZATION
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 43
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 14017422