Synthesis of Schiff Based E-4-(((1H-indol-3-yl)methylene) amino)-N-(pyrimidin-2-yl)benzenesulfonamide it's Highly Sensitive and Selective of Turn-on Chemosensor for Recognition of Pb2+ ion.

A Schiff base of E-4-(((1H-indol-3-yl)methylene)amino)-N-(pyrimidin-2-yl)benzene sulfonamide (IMAPB) were synthesized and characterized by FT-IR, ¹H & ¹³C NMR, Mass spectroscopy. Uv-vis spectroscopic measurement probe IMAPB of absorption band 296 nm was observed. The fluorescence intensity at 428 nm was obtained due to turn-on chemosensors for selectivity and sensitivity of Pb²⁺ ion with the interference of other metal ions. The stoichiometric of 1:1 complex formation of IMAPB+Pb²⁺ to confirmed association constant value at 2.3×10⁻⁴ M⁻¹ (R²=0.94976). The PET mechanism was binding with IMAPB+Pb²⁺ linked nitrogen and oxygen. Competitive metal ions to select Pb²⁺ metal ions compared other metal ions. EDTA solution binding of IMAPB+Pb²⁺ with result fluorescence ON, however, different pH range was used in probe of IMAPB+Pb²⁺. The cytotoxicity activity of IMAP used different concentration used HeLa cells. [ABSTRACT FROM AUTHOR]