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Small intestinal bacterial overgrowth is associated with Diarrhea-predominant irritable bowel syndrome by increasing mainly Prevotella abundance.
- Source :
- Scandinavian Journal of Gastroenterology; Dec2019, Vol. 54 Issue 12, p1419-1425, 7p
- Publication Year :
- 2019
-
Abstract
- Objective: Diarrhea-predominant irritable bowel syndrome (IBS-D) is the main subtype of IBS, a chronic functional gastrointestinal disorder. Small intestinal bacterial overgrowth (SIBO), which is characterized by dysbiosis of the bowel, causes gastrointestinal symptoms quite similar to IBS-D. However, whether SIBO correlates with IBS-D and its further mechanism remain unknown. Materials and Methods: The study included 60 IBS-D patients that fulfilled Rome IV criteria and 60 healthy controls. All subjects were undergoing a lactose breath test (LBT) to diagnose SIBO. IBS-D patients were further assigned to negative SIBO (SIBO<superscript>-</superscript>) subgroup and positive SIBO (SIBO<superscript>+</superscript>) subgroup to analyze the scores of symptoms and differences in the fecal microbiota. Results: The prevalence of SIBO in IBS-D patients was higher than that in healthy controls (51.7% vs. 16.7%, p ≤.001). In addition, IBS-SSS in SIBO<superscript>+</superscript> subgroup was significantly higher than SIBO<superscript>-</superscript> subgroup (p =.015). The 16S rRNA analyses showed that composition and abundance of fecal microbiota were obviously different between the two subgroups. There was a remarkable increase in Prevotella in IBS-D patients, especially in IBS-D SIBO<superscript>+</superscript> sufferers. Meanwhile, there were a moderately positive correlation of the abundance of Prevotella (rho = 0.458, p ≤.001) with IBS-SSS. Conclusion: SIBO is associated with IBS-D, which may be related to alteration in the intestinal microbiota. These findings suggest the potent role of Prevotella in gastrointestinal symptoms between SIBO and IBS-D, thus provide a novel insight into the connection between SIBO and IBS-D. [ABSTRACT FROM AUTHOR]
- Subjects :
- SMALL intestinal bacterial overgrowth
IRRITABLE colon
PREVOTELLA
GUT microbiome
Subjects
Details
- Language :
- English
- ISSN :
- 00365521
- Volume :
- 54
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Scandinavian Journal of Gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 140467293
- Full Text :
- https://doi.org/10.1080/00365521.2019.1694067