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Bi(OAc)3/chiral phosphoric acid catalyzed enantioselective allylation of isatins.

Authors :
Wang, Jie
Zhang, Qingxia
Li, Yao
Liu, Xiangshuai
Li, Xin
Cheng, Jin-Pei
Source :
Chemical Communications; 1/7/2020, Vol. 56 Issue 2, p261-264, 4p
Publication Year :
2020

Abstract

Herein, we disclosed an efficient protocol for the construction of chiral 3-allyl-3-hydroxyoxindoles via the enantioselective allylation reaction of isatins and allylboronates catalyzed by a simple binary acid Bi(OAc)<subscript>3</subscript>/CPA system under mild conditions. The synthetic utility of this strategy has been demonstrated through the formal synthesis of ent-CPC-1. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
ALLYLATION
PHOSPHORIC acid

Details

Language :
English
ISSN :
13597345
Volume :
56
Issue :
2
Database :
Complementary Index
Journal :
Chemical Communications
Publication Type :
Academic Journal
Accession number :
140474480
Full Text :
https://doi.org/10.1039/c9cc07944k