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Thymocyte emigration in the chicken: an over-representation of CD4+ cells over CD8+ in the periphery.
- Source :
- Immunology; Nov96, Vol. 89 Issue 3, p419-423, 5p
- Publication Year :
- 1996
-
Abstract
- We have examined the emigration of chicken thymocytes after intrathymic fluorescein isothiocyanate (FITC) labelling in situ. In this paper we show that in young birds about 0.7% and 0.4% of thymocytes emigrate from the thymus to the blood and the spleen, respectively, per day. This suggests that, as in mammals, most thymocytes die within the thymus. At 3 weeks of age γδ and αβ T cells leave the thymus in comparable levels to their appearance in the blood. The phenotype of recent emigrants in peripheral tissues is similar to that of mature T cells. Interestingly, recent emigrants contain relatively much higher numbers of CD4<superscript>+</superscript> and fewer CD8<superscript>+</superscript> cells than is observed in peripheral tissues in a steady-state situation. [ABSTRACT FROM AUTHOR]
- Subjects :
- CD antigens
GLYCOPROTEINS
FC receptors
CELL surface antigens
IMMUNOGLOBULINS
IMMUNITY
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 89
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 14054378
- Full Text :
- https://doi.org/10.1046/j.1365-2567.1996.d01-764.x