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Distribution of porcine CD4/CD8 double-positive T lymphocytes in mucosa-associated lymphoid tissues.
- Source :
- Immunology; Mar96, Vol. 87 Issue 3, p493-499, 7p
- Publication Year :
- 1996
-
Abstract
- The present study describes the distribution of CD4/CD8 double-positive (DP) T cells in lymph nodes and mucosa-associated lymphoid tissues of pigs at 6–7 months of age. Proportions of lymphocytes isolated from peripheral, bronchial and mesenteric lymph nodes expressing CD4 and/ or CD8 molecules were similar and ranged from 10-13% CD4/CD8 DP cells, 25-27% CD4 single-positive (SP) cells, and 27-32% CD8 SP cells. Mucosa-associated lymphoid tissues had significantly smaller proportions of CD4<superscript>+</superscript> and/or CD8<superscript>+</superscript> T cells than lymph nodes and CD4/CD8 DP cells accounted for a larger proportion of the total CD4<superscript>+</superscript> lymphocytes than in lymph nodes. Compared to the lymph nodes, the predominant CD4<superscript>+</superscript> and/or CD8<superscript>+</superscript> T-cell subset in tonsils was the CD4/CD8 DP population (18%), because of both a higher proportion of these cells and a lower proportion of CD4 SP (12%) and CD8 SP (14%) lymphocyte subsets. Jejunal Peyer's patches were comprised of 12% CD4 SP, 28% CD8 SP and 10% CD4/CD8 DP lymphocytes. In contrast, the mid-section of the continuous Peyer's patch in the ileum contained 7% CD4 SP, 8% CD8 SP and 4% CD4/CD8 DP lymphocytes. The distribution of T lymphocytes in porcine mucosal lymphoid aggregates agrees with the reported correlation between high and low rates of lymphocyte entry into these tissues and the abundance or scarcity of T cells, respectively. Defining the role of CD4/CD8 DP lymphocytes and their unique distribution in mucosa-associated lymphoid tissues in the pig may reveal novel T-cell-mediated regulatory pathways. [ABSTRACT FROM AUTHOR]
- Subjects :
- CD antigens
LABORATORY animals
IMMUNE system
T cells
LYMPH nodes
IMMUNOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 87
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 14086426
- Full Text :
- https://doi.org/10.1046/j.1365-2567.1996.494570.x