The relationship between aberrant methylation and survival in non-small-cell lung cancers.

Authors :: Toyooka, S.
Suzuki, M.
Maruyama, R.
Toyooka, K. O.
Tsukuda, K.
Fukuyama, Y.
T. Iizasa
Aoe, M.
Date, H.
Fujisawa, T.
Shimizu, N.
Gazdar, A. F.
Iizasa, T
Source :: British Journal of Cancer; 8/16/2004, Vol. 91 Issue 4, p771-774, 4p
Publication Year :: 2004
Abstract: The present study examined the relationship between methylation of five genes (p16(INK4a), RASSF1A, APC, RARbeta and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes and survival, p16(INK4a) methylation was significantly related to unfavourable prognosis in lung adenocarcinomas. [ABSTRACT FROM AUTHOR]

Subjects :: METHYLATION
ALKYLATION
LUNG cancer
GENES
CANCER patients
ADENOCARCINOMA
DNA metabolism
COMPARATIVE studies
LUNG tumors
RESEARCH methodology
MEDICAL cooperation
ONCOGENES
RESEARCH
SURVIVAL analysis (Biometry)
EVALUATION research
RETROSPECTIVE studies
DNA methylation

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