Trends in mortality rates for Stevens–Johnson syndrome and toxic epidermal necrolysis: experience of a single centre in France between 1997 and 2017.

Dear Editor, Epidermal necrolysis (EN) is a rare life-threatening disease, caused mostly by drugs.[[1]] The spectrum of EN includes Stevens-Johnson syndrome [SJS, detached or detachable body surface area (BSA) < 10%], overlap syndrome (10-29% BSA) and toxic epidermal necrolysis (TEN) or Lyell syndrome (>= 30% BSA). Mortality rates range from 14-7% to 29-4%.[[3]] We performed a retrospective, single-centre cohort study to investigate the changes in mortality rate between 1997 and 2017 for patients with EN. According to the maximal BSA involved, the final diagnosis for 335 patients (missing data I n i = 26) was SJS for 127 (38%) patients, overlap syndrome for 75 (22%) and TEN for 133 (40%). [Extracted from the article]