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Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin.
- Source :
- Chemical Communications; 1/16/2020, Vol. 56 Issue 5, p822-825, 4p
- Publication Year :
- 2020
-
Abstract
- Produced by a newly isolated Streptomycetes strain, meijiemycin is a gigantic linear polyene-polyol that exhibits structural features not seen in other members of the polyene-polyol family. We propose a biosynthetic mechanism and demonstrate that meijiemycin inhibits hyphal growth by inducing the aggregation of ergosterol and restructuring of the fungal plasma membrane. [ABSTRACT FROM AUTHOR]
- Subjects :
- ERGOSTEROL
FUNGAL membranes
BIOSYNTHESIS
CELL membranes
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 56
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 141232062
- Full Text :
- https://doi.org/10.1039/c9cc08908j