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Allostatic stress load and CMV serostatus impact immune response to maximal exercise in collegiate swimmers.
- Source :
- Journal of Applied Physiology; Jan2020, Vol. 128 Issue 1, p178-188, 11p
- Publication Year :
- 2020
-
Abstract
- Collegiate athletes are exposed to varying levels of academic and physical stressors, placing them at increased risk for stress-activated latent viral infections. However, the impact of allostatic stress load on the immune response to maximal exercise in athletes remains largely unknown. This study examined the effects of a 7-mo training period and cytomegalovirus (CMV) serostatus on immune cell response to high-intensity swim tests within a group of collegiate swimmers. Samples were collected from 15 National Collegiate Athletic Association Division I swimmers (9 men, 6 women: 19.87 ± 0.64 yr) before and after exhaustive in-pool swims at 2 time points (V<subscript>1</subscript>: immediately post-season 1 and V<subscript>3</subscript>: beginning of season 2). An additional off-season (V<subscript>2</subscript>) time point was collected in a subset of 9 swimmers. Natural killer (NK) cell, B cell, and T cells were quantified by flow cytometry. Linear mixed models were used to determine the effects of exercise, time point, and CMV serostatus (α = 0.05). Resting senescent CD8+ T cells were higher in CMVseropositive participants at V<subscript>3</subscript> (P = 0.005). CMV-seronegative participants had a decrease in resting senescent CD8+ T cells from V<subscript>1</subscript> to V<subscript>3</subscript> (P = 0.021). After acute exercise, CMV-seropositive participants had lower naïve CD8+ T cells (P < 0.001) and higher senescent CD8+ T cells (P < 0.001). Increased cumulative stress levels did not appear to affect B-cell and NK-cell compartments. Immune response to exercise was impacted by CMV serostatus and allostatic stress load. Young CMV-seropositive athletes exposed to elevated stressors should be monitored to determine long-term effects of training and academic stressors. [ABSTRACT FROM AUTHOR]
- Subjects :
- SWIMMERS
LATENT infection
ATHLETES
IMMUNE response
T cells
EXERCISE
COLLEGE athletes
Subjects
Details
- Language :
- English
- ISSN :
- 87507587
- Volume :
- 128
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Applied Physiology
- Publication Type :
- Academic Journal
- Accession number :
- 141284284
- Full Text :
- https://doi.org/10.1152/japplphysiol.00646.2019