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A photoelectrochemical immunosensor based on CdS/CdTe-cosensitized SnO2 as a platform for the ultrasensitive detection of amyloid β-protein.
- Source :
- Analyst; 1/21/2020, Vol. 145 Issue 2, p619-625, 7p
- Publication Year :
- 2020
-
Abstract
- An ultrasensitive label-free photoelectrochemical (PEC) immunosensor was developed to detect amyloid β-protein (Aβ) based on CdS/CdTe-cosensitized SnO<subscript>2</subscript> nanoflowers. Specifically, SnO<subscript>2</subscript> with a flower-like porous nanostructure was utilized as a perfect substrate for the construction of PEC immunosensors, and the SnO<subscript>2</subscript>-modified electrode was first coated with CdTe quantum dots (QDs) and then further deposited with CdS by successive ionic layer adsorption and reaction techniques. The formed SnO<subscript>2</subscript>/CdS/CdTe-cosensitized structure exhibited excellent photocurrent intensity and was employed as an excellent photoactive matrix to immobilize Aβ antibody to further construct the immunosensor. Under optimal conditions, the as-constructed PEC immunosensor was used to detect Aβ and exhibited a wide linear concentration range from 0.5 pg mL<superscript>−1</superscript> to 10 ng mL<superscript>−1</superscript>, with a low limit of detection (LOD, 0.18 pg mL<superscript>−1</superscript>, S/N = 3). Meanwhile, it also presented good reproducibility, specificity, and stability and may open a new promising platform for the clinical detection of Aβ or other biomarkers. [ABSTRACT FROM AUTHOR]
- Subjects :
- QUANTUM dots
DETECTION limit
AMYLOID
AMYLOID beta-protein
Subjects
Details
- Language :
- English
- ISSN :
- 00032654
- Volume :
- 145
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Analyst
- Publication Type :
- Academic Journal
- Accession number :
- 141289839
- Full Text :
- https://doi.org/10.1039/c9an01848d