Back to Search
Start Over
Effects of Cyclic GMP-Agonists on Ciclosporin-Induced Suppression of Human Lymphokine Production.
- Source :
- Allergy; Oct85, Vol. 40 Issue 7, p529-534, 6p
- Publication Year :
- 1985
-
Abstract
- Ciclosporin (Cs) inhibits the elaboration of the lymphokine leukocyte migration inhibitory factor (LIF) from human blood mononuclear cells (MNC) stimulated with recall antigen. This inhibition was counteracted by 3 &time; l0<superscript>-3</superscript> M dibutyryl-cyclic GMP and 8-bromo-cyclic GMP and by the cyclic GMP-agonists, sodium nitroprusside (NaNPr), ascorbic acid (As A), sodium azide (NaN<subscript>3</subscript>) and carbacholine. Using 5 &time; l0<superscript>-5</superscript> M NaNPr, 1 &time; l0<superscript>-3</superscript> M NaN<subscript>3</subscript>, or 3 &time; 10<superscript>-3</superscript> M As A<subscript>1</subscript> 25-50-, 4-8- and 2-3-fold elevations of MNC and T-lymphocyte cyclic GMP-levels were obtained independently of the presence of Cs. NaNPr was the most potent of these three cyclic GMP-agonists in counteracting the effect of Cs. The results indicate that intracellular cyclic GMP is a major factor involved in the reversal of Cs-induced inhibition of LIF-production. None of the cyclic GMP-analogues or -agonists by themselves possessed Interleukin 1-like activity, measured by their ability to induce LIF-production by macrophage-depleted T-lymphocytes challenged by recall antigen. [ABSTRACT FROM AUTHOR]
- Subjects :
- LYMPHOKINES
LEUCOCYTES
ANTIGENS
T cells
LYMPHOCYTES
IMMUNITY
Subjects
Details
- Language :
- English
- ISSN :
- 01054538
- Volume :
- 40
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Allergy
- Publication Type :
- Academic Journal
- Accession number :
- 14132233
- Full Text :
- https://doi.org/10.1111/j.1398-9995.1985.tb00262.x