Back to Search
Start Over
Polymorphism of the Interleukin-1β Gene and Endometriosis.
- Source :
- Reproductive Sciences; Apr2003, Vol. 10 Issue 3, p172-175, 4p
- Publication Year :
- 2003
-
Abstract
- Objective: Experimental data indicate that interleukin (IL)-1 plays a role in the pathogenesis of endometriosis. We determined the genotype and the allele frequencies of the IL1B exon 5 polymorphism and the corresponding IL-1β serum levels in women with endometriosis. Methods: We genotyped 92 women with surgically and histologically confirmed endometriosis and 69 controls without history of endometriosis. Both groups were of middle Euroepan genetic background for the IL1B exon 5 polymorphism (at position +3954). Genotyping was performed by pyrosequencing. IL-1β serum levels were anlayzed by a commercially available enzyme-linked immunosorbent assay. Results: Allele frequencies in women with endometriosis and control swere 76.6% and 76.8%, respectively, for the E1 allele (wild type) and 23.4% and 23.2%, respectively, for the E2 allele (polymorphic) (odds ratio 1.01; P >.99). The investigated polymorphism of the IL-1β gene was not correlated with IL-1β serum levels. Conclusion: We did not find an association between the IL1B exon 5 polymorphism, endometriosis, or increased serum IL-1η levels. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19337191
- Volume :
- 10
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Reproductive Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 141391639
- Full Text :
- https://doi.org/10.1016/S1071-5576(03)00006-6