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Omega-3 and hemocompatibility-related adverse events.
- Source :
- Journal of Cardiac Surgery; Feb2020, Vol. 35 Issue 2, p405-412, 8p, 5 Charts, 4 Graphs
- Publication Year :
- 2020
-
Abstract
- <bold>Background: </bold>Hemocompatibility-related clinical adverse events (HRAEs) are major causes of readmission in patients with left ventricular assist devices (LVADs). Omega-3 is an unsaturated fatty acid that possesses anti-inflammatory and antiangiogenic properties. We aimed to investigate the impact of omega-3 therapy on HRAEs during LVAD support.<bold>Methods: </bold>Consecutive LVAD patients who were followed for 6 months were enrolled, and stratified by the use of omega-3. Freedom from any HRAEs and net burden of HRAEs, which was calculated by using a hemocompatibility score (using 4 escalating tiers of hierarchal severity to derive a total score for events), were compared between those with and without omega-3 therapy.<bold>Results: </bold>Among 169 LVAD patients (57 years old and 124 males), 31 patients received 4 g/d of omega-3 therapy and 138 patients were in the control group. During the 6-month observational period, freedom from any HRAEs was 90% in the omega-3 group compared with 70% in the control group with a hazard ratio of 0.35 (95% confidence interval 0.11-0.87 and P = .042). The average hemocompatibility score in the omega-3 group was significantly lower compared with the control group (0.23 vs 0.91; P = .042), due to reduced Tier I scores (mild HRAE; P = .003) and Tier IIIB scores (severe HRAE; P < .001). The similar trends remained at propensity-matched populations.<bold>Conclusions: </bold>Omega-3 therapy was associated with reduced HRAEs including both bleeding and thromboembolic events in LVAD patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08860440
- Volume :
- 35
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Cardiac Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 141395704
- Full Text :
- https://doi.org/10.1111/jocs.14384