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The Traditional Chinese Medicine Fufang Shatai Heji (STHJ) Enhances Immune Function in Cyclophosphamide-Treated Mice.
- Source :
- Evidence-based Complementary & Alternative Medicine (eCAM); 1/23/2020, p1-12, 12p, 1 Diagram, 7 Graphs
- Publication Year :
- 2020
-
Abstract
- Fufang Shatai Heji (STHJ) is a mixture of traditional Chinese medicines, such as Radix Adenophorae, Radix Pseudostellariae, and Radix Astragali. STHJ is commonly used to treat diseases caused by low immune function, for example, Sjögren's syndrome (SS). The primary objective of this study was to assess the immunopotentiating effect of STHJ using an immunosuppressive mouse model receiving cyclophosphamide (CTX). Following CTX treatment, STHJ was administered by oral gavage for 30 consecutive days. The percentage of specific lymphocyte subpopulations in the spleen was measured by flow cytometry. Levels of inflammatory factors in serum were detected by enzyme-linked immunosorbent assays (ELISAs). The administration of STHJ significantly elevated thymus and spleen indices, increased B cell and natural killer (NK) cell activities, and decreased CD8<superscript>+</superscript> T, CD8<superscript>+</superscript>CD122<superscript>+</superscript> T, NKT, and γδT cell activities in the CTX-treated mice. In addition, STHJ upregulated the expression of interleukin- (IL-) 2, IL-6, and tumor necrosis factor-α (TNF-α) and downregulated IL-10 expression in CTX-treated mice. In conclusion, STHJ effectively remitted CTX-induced immunosuppression by modulating the balance of lymphocyte subsets and cytokines. Our results suggest STHJ treatment could be used as an effective therapeutic approach to improve immune function in patients with low immunity. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANIMAL experimentation
ANTIGENS
B cells
CYTOKINES
ENZYME-linked immunosorbent assay
FLOW cytometry
GENE expression
HERBAL medicine
INFLAMMATORY mediators
INTERLEUKINS
KILLER cells
LYMPHOCYTES
CHINESE medicine
MICE
MOLECULAR structure
SPLEEN
THYMUS
TUMOR necrosis factors
CYCLOPHOSPHAMIDE
DRUG administration
DRUG dosage
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Database :
- Complementary Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 141398622
- Full Text :
- https://doi.org/10.1155/2020/3849847