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Preparation of Cholesteryl-Modified Aminated Pullulan Nanoparticles to Evaluate Nanoparticle of Hydrophobic Degree on Drug Release and Cytotoxicity.
- Source :
- Journal of Nanomaterials; 1/17/2020, p1-11, 11p
- Publication Year :
- 2020
-
Abstract
- The formation of nanoparticles (NPs) and surface properties such as size and charge are affected by the amphiphilic property of polymer, which is vital for evaluating their function. Here, we synthesized cholesteryl-modified aminated pullulan polymers (CHPNs) with different amounts of cholesterol succinate (CHS). We characterized the three hydrophobically modified polymers (CHPN<subscript>1</subscript>, CHPN<subscript>2</subscript>, and CHPN<subscript>3</subscript>) (CHS: Pu ‐ N H 2 = 1 / 5 , 2 / 5 , 3 / 5) by Fourier transform infrared spectrometry. Dynamic light scattering (DLS) was used to measure particle size and zeta potential of CHPN NPs. The particle sizes of the three NPs CHPN<subscript>1</subscript>, CHPN<subscript>2</subscript>, and CHPN<subscript>3</subscript> were 178.0, 144.4, and 97.8 nm, respectively. The particle size was related to the cholesteryl substitution of polymers to a certain extent: the stronger the hydrophobicity, the smaller the particle size. In 48 h, the drug release for CHPN<subscript>3</subscript> and CHPN<subscript>1</subscript> NPs was 57.8% and 72.7%. Thus, the NPs showed good sustained drug release: the greater the degree of hydrophobic substitution, the better the sustained release. The cytotoxicity findings were reversed: CHPN<subscript>1</subscript> NPs, with low hydrophobic substitution, showed the best inhibition of Lewis lung cancer cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16874110
- Database :
- Complementary Index
- Journal :
- Journal of Nanomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 141398631
- Full Text :
- https://doi.org/10.1155/2020/7171209