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Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions.
- Source :
- Nature Communications; 1/27/2020, Vol. 11 Issue 1, p1-18, 18p
- Publication Year :
- 2020
-
Abstract
- Lymphatic endothelial cells (LECs) chemoattract naïve T cells and promote their survival in the lymph nodes, and can cross-present antigens to naïve CD8<superscript>+</superscript> T cells to drive their proliferation despite lacking key costimulatory molecules. However, the functional consequence of LEC priming of CD8<superscript>+</superscript> T cells is unknown. Here, we show that while many proliferating LEC-educated T cells enter early apoptosis, the remainders comprise a long-lived memory subset, with transcriptional, metabolic, and phenotypic features of central memory and stem cell-like memory T cells. In vivo, these memory cells preferentially home to lymph nodes and display rapid proliferation and effector differentiation following memory recall, and can protect mice against a subsequent bacterial infection. These findings introduce a new immunomodulatory role for LECs in directly generating a memory-like subset of quiescent yet antigen-experienced CD8<superscript>+</superscript> T cells that are long-lived and can rapidly differentiate into effector cells upon inflammatory antigenic challenge. Lymphatic endothelial cells (LECs) can cross-present antigen to naïve CD8<superscript>+</superscript> T cells, but the significance of this interaction was unclear. Here the authors show that LECs directly induce CD8<superscript>+</superscript> T cell differentiation with memory-like phenotypes, migration patterns and transcriptome, which can later be recalled to promote effector immunity and protection from Listeria infection. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- 141413631
- Full Text :
- https://doi.org/10.1038/s41467-019-14127-9