Back to Search
Start Over
Enantioselective Difunctionalization of Alkenes by a Palladium‐Catalyzed Heck/Sonogashira Sequence.
- Source :
- Angewandte Chemie International Edition; 2/10/2020, Vol. 59 Issue 7, p2769-2775, 7p
- Publication Year :
- 2020
-
Abstract
- Sonogashira‐type cross‐couplings are one of the most significant alkynylations in organic chemistry. One of the first palladium‐catalyzed intramolecular Heck/Sonogashira reactions of alkenes with terminal alkynes is now reported. With this method, a variety of uniquely substituted chiral benzene‐fused heterocycles bearing a propargyl‐substituted all‐carbon quaternary stereocenter were obtained in a straightforward, high‐yielding, and highly stereoselective manner under mild conditions. Salient features of this process include the use of readily available substrates, high selectivities, a broad substrate scope as well as versatile product functionalizations. [ABSTRACT FROM AUTHOR]
- Subjects :
- PALLADIUM
ALKENES
BENZENE derivatives
ORGANIC chemistry
SONOGASHIRA reaction
ALKYNES
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 59
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 141526413
- Full Text :
- https://doi.org/10.1002/anie.201913367