Back to Search
Start Over
New ASGPR-targeted ligands based on glycoconjugated natural triterpenoids.
- Source :
- Russian Chemical Bulletin; Dec2019, Vol. 68 Issue 12, p2331-2338, 8p
- Publication Year :
- 2019
-
Abstract
- New ligands for targeted delivery to the liver based on glycoconjugated natural triterpenoids are proposed. Simple chemical transformations of starting lupane triterpenes led to betulin or betulinic acid conjugates with N-acetyl-d-galactosamine linked through an isopropenyl fragment of the terpene skeleton. The obtained compounds were non-toxic in vitro to a series of cancer cell lines and normal cells. Molecular docking in silico and surface plasmon resonance spectroscopy revealed a high specificity of the synthesized glycotriterpenoids to the asialogly-coprotein receptor of hepatocytes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10665285
- Volume :
- 68
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Russian Chemical Bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 141561403
- Full Text :
- https://doi.org/10.1007/s11172-019-2707-9