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Quinine Enhances Photo-Inactivation of Gram-Negative Bacteria.
- Source :
- Journal of Infectious Diseases; 2/15/2020, Vol. 221 Issue 4, p618-626, 9p
- Publication Year :
- 2020
-
Abstract
- <bold>Background: </bold>Antimicrobial resistance is a significant concern to public health, and there is a pressing need to develop novel antimicrobial therapeutic modalities.<bold>Methods: </bold>In this study, we investigated the capacity for quinine hydrochloride (Q-HCL) to enhance the antimicrobial effects of antimicrobial blue light ([aBL] 405 nm wavelength) against multidrug-resistant (MDR) Gram-negative bacteria in vitro and in vivo.<bold>Results: </bold>Our findings demonstrated the significant improvement in the inactivation of MDR Pseudomonas aeruginosa and Acinetobacter baumannii (planktonic cells and biofilms) when aBL was illuminated during Q-HCL exposure. Furthermore, the addition of Q-HCL significantly potentiated the antimicrobial effects of aBL in a mouse skin abrasion infection model. In addition, combined exposure of aBL and Q-HCL did not result in any significant apoptosis when exposed to uninfected mouse skin.<bold>Conclusions: </bold>In conclusion, aBL in combination with Q-HCL may offer a novel approach for the treatment of infections caused by MDR bacteria. [ABSTRACT FROM AUTHOR]
- Subjects :
- GRAM-negative bacteria
QUININE
ACINETOBACTER baumannii
BLUE light
PSEUDOMONAS aeruginosa
SKIN infections
ANTIBIOTICS
PSEUDOMONAS physiology
SKIN microbiology
SKIN injuries
MICROBIOLOGY of wounds
ACINETOBACTER infections
ANIMAL experimentation
BIOFILMS
COMPARATIVE studies
DRUG resistance in microorganisms
RESEARCH methodology
MEDICAL cooperation
MICE
MICROBIAL sensitivity tests
PLANKTON
PSEUDOMONAS
MEDICAL radiology
RESEARCH
SKIN
ULTRAVIOLET radiation
EVALUATION research
TREATMENT effectiveness
GRAM-negative aerobic bacteria
PHARMACODYNAMICS
PHYSIOLOGICAL effects of radiation
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 221
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 141566015
- Full Text :
- https://doi.org/10.1093/infdis/jiz487