Back to Search
Start Over
Hsa-let-7b Suppresses Cell Proliferation by Targeting UHRF1 in Melanoma.
- Source :
- Cancer Investigation; 2020, Vol. 38 Issue 1, p52-60, 9p
- Publication Year :
- 2020
-
Abstract
- UHRF1 promotes melanoma progression by inducing cell proliferation, and is correlated with poor prognosis of melanoma patients. However, the regulation mechanism has not been fully elaborated. Here, we detected hsa-let-7b expression and its role in melanoma. Through Targetscan and miRanda predication, 30 overlapped miRNAs were found; further survival analysis revealed that hsa-let-7b was the only miRNA that affected the overall survival. Overexpressed hsa-let-7b could significantly inhibit the proliferation ability of A375 and A2058 cells, and this phenomenon was reversed after co-transfection with pLenti-UHRF1. In conclusion, hsa-let-7b regulates melanoma cells proliferation in vitro by targeting UHRF1. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07357907
- Volume :
- 38
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Cancer Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 141601441
- Full Text :
- https://doi.org/10.1080/07357907.2019.1709482