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Allergic bronchial asthma: eosinophil chemotaxis and antihistaminic drug modulation.
- Source :
- Allergy; Nov96, Vol. 51 Issue 11, p777-781, 5p
- Publication Year :
- 1996
-
Abstract
- This paper investigated the chemotactic capacity of blood eosinophils (EOS) in response to C5a and formyl-leucyl-phenylalanine (FMLP) in 15 <em>Parietaria</em>- pollen-allergic patients with mild asthma during the <em>Parietaria</em> pollen season. Data showed that EOS chemotaxis toward C5a was significantly reduced during the peak pollen count, compared with the values obtained in normal subjects. On the other hand, FMLP could induce EOS chemotactic activity only in <em>Parietaria</em>-allergic patients, the highest value being registered during the height of the <em>Parietaria</em> season. <em>In vitro</em> cimetidine modulation of chemotactic function in comparison with C5a led to a recovery of the impaired results obtained in the presence of high histamine levels. Moreover, diphenhydramine preincubation of EOS induced a reduction of the enhanced chemotactic activity obtained with low concentrations. The data suggest that different serum histamine levels give rise to an impaired immune-phlogistic response in allergic patients and that histamine-receptor antagonists may modulate this effect. [ABSTRACT FROM AUTHOR]
- Subjects :
- ASTHMA
CHEMOTAXIS
EOSINOPHILS
ANTIHISTAMINES
ALLERGIES
OBSTRUCTIVE lung diseases
Subjects
Details
- Language :
- English
- ISSN :
- 01054538
- Volume :
- 51
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Allergy
- Publication Type :
- Academic Journal
- Accession number :
- 14166598
- Full Text :
- https://doi.org/10.1111/j.1398-9995.1996.tb00022.x