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Anti-reflux mucosectomy using a cap-assisted endoscopic mucosal resection method for refractory gastroesophageal disease: a prospective feasibility study.
- Source :
- Surgical Endoscopy & Other Interventional Techniques; Mar2020, Vol. 34 Issue 3, p1124-1131, 8p, 1 Color Photograph, 3 Charts, 1 Graph
- Publication Year :
- 2020
-
Abstract
- <bold>Background and Aims: </bold>Endoscopic therapy of gastroesophageal reflux disease (GERD) overcomes the "treatment gap" for patients with refractory GERD, who are not willing to go into surgery. We propose an easy and efficient technique that is referred to as anti-reflux mucosectomy (ARMS) using cap-assisted endoscopic mucosal resection (EMR-C) which could be called ARMS-C. This study aimed to investigate the short-term outcomes of ARMS-C in GERD patients.<bold>Methods: </bold>From December 2016 to February 2018, we performed ARMS-C in 33 patients with pathologic reflux disease and esophageal hypersensitivity. ARMS-C involved endoscopic mucosal resection at the circumference of the esophagogastric junction (EGJ), resulting in narrowing of the hiatal opening after healing. The GERD symptoms, 24-h pH monitoring results, manometry, endoscopy, and EGJ distensibility were compared before and after the procedure.<bold>Results: </bold>Six months after ARMS-C, 63% of patients discontinued the use of pump inhibitors (PPIs), while 30% patients reduced their PPI dose. The GERD questionnaire scores significantly decreased after ARMS-C, from 11.0 to 6.0 (P < 0.001). The median DeMeester score and acid exposure time based on pH monitoring also improved after ARMS-C. Furthermore, the median flap valve grade and EGJ distensibility decreased from 3.0 to 1.0 (P < 0.001) and from 19.0 to 13.9 (P < 0.001), respectively. Two patients were treated with balloon dilation due to stricture, but no other serious adverse events were encountered.<bold>Conclusion: </bold>ARMS-C may be an effective and safe treatment method for GERD in terms of short-term outcomes. [ABSTRACT FROM AUTHOR]
- Subjects :
- ENDOSCOPIC surgery
ESOPHAGOGASTRIC junction
LONGITUDINAL method
FEASIBILITY studies
GASTROESOPHAGEAL reflux
INTRA-aortic balloon counterpulsation
MEDICAL balloons
ESOPHAGEAL surgery
PILOT projects
RESEARCH
CLINICAL trials
RESEARCH methodology
MEDICAL cooperation
EVALUATION research
TREATMENT effectiveness
COMPARATIVE studies
Subjects
Details
- Language :
- English
- ISSN :
- 18666817
- Volume :
- 34
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Surgical Endoscopy & Other Interventional Techniques
- Publication Type :
- Academic Journal
- Accession number :
- 141681279
- Full Text :
- https://doi.org/10.1007/s00464-019-06859-y