Back to Search
Start Over
The Antiosteoporosis Effects of Yishen Bugu Ye Based on Its Regulation on the Differentiation of Osteoblast and Osteoclast.
- Source :
- BioMed Research International; 2/21/2020, p1-12, 12p
- Publication Year :
- 2020
-
Abstract
- Yishen Bugu Ye (YSBGY), a traditional Chinese medicine comprising 12 types of medicinal herbs, is often prescribed in China to increase bone strength. In this study, the antiosteoporotic effects of YSBGY were investigated in C57BL/6 mice afflicted with dexamethasone- (Dex-) induced osteoporosis (OP). The results showed that YSBGY reduced the interstitial edema in the liver and kidney of mice with Dex-induced OP. It also increased the number of trabecular bone elements and chondrocytes in the femur, promoted cortical bone thickness and trabecular bone density, and modulated the OP-related indexes in the femur and tibia of OP mice. It also increased the serum concentrations of type I collagen, osteocalcin, osteopontin, bone morphogenetic protein-2, bone morphogenetic protein receptor type 2, C-terminal telopeptide of type I collagen, and runt-related transcription factor-2 and reduced those of tartrate-resistant acid phosphatase 5 and nuclear factor of activated T cells in these mice, suggesting that it improved osteoblast differentiation and suppressed osteoclast differentiation. The anti-inflammatory effect of YSBGY was confirmed by the increase in the serum concentrations of interleukin- (IL-) 33 and the decrease in concentrations of IL-1, IL-7, and tumor necrosis factor-α in OP mice. Furthermore, YSBGY enhanced the serum concentrations of superoxide dismutase and catalase in these mice, indicating that it also exerted antioxidative effects. This is the first study to confirm the antiosteoporotic effects of YSBGY in mice with Dex-induced OP, and it showed that these effects may be related to the YSBGY-induced modulation of the osteoblast/osteoclast balance and serum concentrations of inflammatory factors. These results provide experimental evidence supporting the use of YSBGY for supporting bone formation in the clinical setting. [ABSTRACT FROM AUTHOR]
- Subjects :
- OSTEOPOROSIS prevention
EDEMA prevention
ACID phosphatase
ANIMAL experimentation
BONE morphogenetic proteins
BONES
CARTILAGE cells
CATALASE
CELL differentiation
CELL receptors
COLLAGEN
COMPACT bone
CYTOKINES
FEMUR
HERBAL medicine
INFLAMMATORY mediators
INTERLEUKINS
KIDNEYS
LIVER
CHINESE medicine
MICE
OSTEOCLASTS
OSTEOPOROSIS
SUPEROXIDE dismutase
T cells
TIBIA
TRANSCRIPTION factors
TUMOR necrosis factors
OXIDATIVE stress
BONE density
DEXAMETHASONE
OSTEOBLASTS
OSTEOCALCIN
CANCELLOUS bone
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Database :
- Complementary Index
- Journal :
- BioMed Research International
- Publication Type :
- Academic Journal
- Accession number :
- 141922477
- Full Text :
- https://doi.org/10.1155/2020/9467683