Back to Search
Start Over
Nasal memory T lymphocytes capable of producing IL-4 in the allergic reaction.
- Source :
- Allergy; Aug92 Part 1, Vol. 47 Issue 4, p334-336, 3p
- Publication Year :
- 1992
-
Abstract
- This paper reports the presence of memory T cells in the nasal mucosa of allergic patients. The demonstration of CD4+/CD29+ (CD4+/CD45RO+) T lymphocytes, which are capable of interleukin-4 production, can indicate a complementary cell-mediated regulatory mechanism for mast cell proliferation and IgE synthesis in human nasal allergy. No substantial IgE production can be obtained in the absence of IL-4. Therefore, the existence of IL-4 producing cells on site in the nasal mucosa of allergic subjects probably implies a complementary interaction between cytokines and different immunocompetent nasal cells in the regulation of B cells and IgE synthesis. [ABSTRACT FROM AUTHOR]
- Subjects :
- LYMPHOCYTES
T cells
ALLERGIES
IMMUNOLOGIC diseases
CYTOKINES
CELLULAR immunity
Subjects
Details
- Language :
- English
- ISSN :
- 01054538
- Volume :
- 47
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Allergy
- Publication Type :
- Academic Journal
- Accession number :
- 14197824
- Full Text :
- https://doi.org/10.1111/j.1398-9995.1992.tb02065.x