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Long noncoding RNAs: new insights in modulating mammalian spermatogenesis.
- Source :
- Journal of Animal Science & Biotechnology; 2/28/2020, Vol. 11 Issue 1, p1-12, 12p
- Publication Year :
- 2020
-
Abstract
- Spermatogenesis is a complex differentiating developmental process in which undifferentiated spermatogonial germ cells differentiate into spermatocytes, spermatids, and finally, to mature spermatozoa. This multistage developmental process of spermatogenesis involves the expression of many male germ cell-specific long noncoding RNAs (lncRNAs) and highly regulated and specific gene expression. LncRNAs are a recently discovered large class of noncoding cellular transcripts that are still relatively unexplored. Only a few of them have post-meiotic; however, lncRNAs are involved in many cellular biological processes. The expression of lncRNAs is biologically relevant in the highly dynamic and complex program of spermatogenesis and has become a research focus in recent genome studies. This review considers the important roles and novel regulatory functions whereby lncRNAs modulate mammalian spermatogenesis. [ABSTRACT FROM AUTHOR]
- Subjects :
- NON-coding RNA
SPERMATOGENESIS
LINCRNA
GERM cells
SPERMATOZOA
GENE expression
Subjects
Details
- Language :
- English
- ISSN :
- 16749782
- Volume :
- 11
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Animal Science & Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 141985073
- Full Text :
- https://doi.org/10.1186/s40104-019-0424-8